Evaluate the Methanol-induced Alzheimer’s Disease Monkey Model by Resting-state Functional MRI
Alzheimer’s disease (AD) is the most comment neurodegenerative disorder that results in the irreversible loss of neurons, especially in the cortex and hippocampus. The aim of this study is to evaluate the changes of brain functional connectivity in methanol-induced AD monkey. To find the corresponding response areas of AD, five brain regions defined by independent component analysis (ICA) were analyzed using seed-based correlation analysis (SCA). Results of resting-sate fMRI showed that the AD Monkey presented abnormal functional connectivity in anterior cingulate cortex (ACC), primary visual cortex (V1) and ventrolateral prefrontal cortex (VLPFC), those were also shown in AD patient.